Author: Esmaeilzadeh, Abdolreza; Elahi, Reza
Title: Immunobiology and immunotherapy of COVIDâ€19: A clinically updated overview Cord-id: y2wpoeo3 Document date: 2020_10_6
ID: y2wpoeo3
Snippet: Severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVIDâ€19). COVIDâ€9 has become a global pandemic with severe health issues around the world. Identifying the accurate immunopathogenesis of the COVIDâ€19 and the immune response against SARSâ€CoVâ€2 is necessary for the development of therapeutic approaches and rational drug design. This paper aims to overview the updated clinical data on the i
Document: Severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVIDâ€19). COVIDâ€9 has become a global pandemic with severe health issues around the world. Identifying the accurate immunopathogenesis of the COVIDâ€19 and the immune response against SARSâ€CoVâ€2 is necessary for the development of therapeutic approaches and rational drug design. This paper aims to overview the updated clinical data on the immunopathogenesis of the COVIDâ€19 and review the innate and adaptive immune response to SARSâ€CoVâ€2. Also, challenges of the immune response to SARSâ€CoVâ€2 leading to dysfunctional immune response and their contribution to the progression of the disease have been discussed. To achieve a more efficient immune response, multiple methods could be applied, including regulation of the immune response, augmentation of the immune system against the virus, inhibition of the dysfunctional immune checkpoints, and inhibition of the viral replication/infection. Based on the immune response against SARSâ€CoVâ€2 and its dysfunction, we introduce potential immunotherapies as well as reviewing recruiting/completed clinical trials of COVIDâ€19.
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