Heparin-binding protein levels correlated with aggravation and multi-organ damage in severe COVID-19

Xue, Mingshan; Zeng, Yifeng; Qu, Hui-Qi; Zhang, Teng; Li, Ning; Huang, Huimin; Zheng, Peiyan; Hu, Haisheng; Zhou, Luqian; Duan, Zhifeng; Zhang, Yong; Bao, Wei; Tian, Li-feng; Hakonarson, Hakon; Zhong, Nanshan; Zhang, Xiaohua Douglas; Sun, Baoqing

BACKGROUND: Critically ill COVID-19 patients may suffer persistent systemic inflammation and multiple organ failure, leading to a poor prognosis. RESEARCH QUESTION: To examine the relevance of the novel inflammatory factor heparin-binding protein (HBP) in critically ill COVID-19 patients, and evaluate the correlation of the biomarker with disease progression. STUDY DESIGN AND METHODS: Eighteen critically ill COVID-19 patients who suffered from respiratory failure and sepsis, including 12 cases who experienced a rapidly deteriorating clinical condition and 6 cases without deterioration, were investigated. They were compared with 15 age- and sex- matched COVID-19 negative patients with respiratory failure. Clinical data were collected and HBP levels were investigated. RESULTS: HBP was significantly increased in critically ill COVID-19 patients following disease aggravation and tracked with disease progression. HBP elevation preceded the clinical manifestations for up to 5 days and was closely correlated with patients’ pulmonary ventilation and perfusion status. INTERPRETATION: HBP levels are associated with COVID-19 disease progression in critically ill patients. As a potential mediator of disease aggravation and multiple organ injuries that are triggered by continuing inflammation and oxygen deficits, HBP warrants further study as a disease biomarker and potential therapeutic target.