Lopinavir/ritonavir f?or the treatment of COVID-19: A living systematic review protocol

Francisca Verdugo-Paiva; Ariel Izcovich; Martin Ragusa; Gabriel Rada

For continuous outcomes, we will use mean difference and standard deviation (SD) to summarise the data using a 95% CI. Whenever continuous outcomes are measured using different scales, the treatment effect will be expressed as a standardised mean difference (SMD) with 95% CI. When possible, we will multiply the SMD by a standard deviation that is representative from the pooled studies, for example, the SD from a well-known scale used by several of the studies included in the analysis on which the result is based. In cases where the minimally important difference (MID) is known, we will also present continuous outcomes as MID units or inform the results as the difference in the proportion of patients achieving a minimal important effect between intervention and control [ 29 ] . Then, these results will be displayed on the 'Summary of Findings Table' as mean difference [ 29 ] .