Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_30
Snippet: Analysis of individual immune cell subsets showed that CD16 + 332 monocytes have a considerably higher level of IFITM3 expression than other 333 cell types in adult blood (Figure 1d ). In lung tissue this level was reduced in 334 the CD16 + monocytes to a level that was comparable to CD14 + monocytes 335 and similar to dendritic cell (DC) populations (pDC were not detected in lung 336 samples) (Figure 1d ). CD14 + monocytes had higher expression .....
Document: Analysis of individual immune cell subsets showed that CD16 + 332 monocytes have a considerably higher level of IFITM3 expression than other 333 cell types in adult blood (Figure 1d ). In lung tissue this level was reduced in 334 the CD16 + monocytes to a level that was comparable to CD14 + monocytes 335 and similar to dendritic cell (DC) populations (pDC were not detected in lung 336 samples) (Figure 1d ). CD14 + monocytes had higher expression of IFITM3 in 337 the lung than blood. Natural Killer (NK) cells showed a slightly increased level 338 of IFITM3 expression in the lung compared to that seen in adult blood. This 339
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