Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_13
Snippet: We calculated nAUC, nW40, nW10, nATY for each participant, and fitted generalized additive models using a spline on age to estimate the association of these metrics with participant age. The nAUC of titers increased with participant age, peaking at ~ 20 years of age for both visits and gradually decreasing to a low at ~ 50 years of age (Fig. 3 , B and C). The average nAUC among participants aged 20 years old was estimated to be higher than that a.....
Document: We calculated nAUC, nW40, nW10, nATY for each participant, and fitted generalized additive models using a spline on age to estimate the association of these metrics with participant age. The nAUC of titers increased with participant age, peaking at ~ 20 years of age for both visits and gradually decreasing to a low at ~ 50 years of age (Fig. 3 , B and C). The average nAUC among participants aged 20 years old was estimated to be higher than that among participants aged 50 years old [ratio: 2.1 (95% CI, 1.9 to 2.4) for baseline and 1.7 (95% CI, 1.5 to 1.9) for follow-up]. After the age of 70, nAUC started to increase.
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