Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress Document date: 2019_6_20
ID: dt0b7jnu_33
Snippet: The increase in mature/cleaved IL1B in Gm15441 LSL mice may at least partially explain the increased expression of Lcn2, Orm2, Saa1 and Saa2 mRNAs by fasting in Gm15441 LSL mouse liver. Taken together, these genes are all associated with inflammation/oxidative stress, consistent with the PPARA-dependent attenuation by Gm15441 of TXNIP-associated hepatic inflammation in response to metabolic stress......
Document: The increase in mature/cleaved IL1B in Gm15441 LSL mice may at least partially explain the increased expression of Lcn2, Orm2, Saa1 and Saa2 mRNAs by fasting in Gm15441 LSL mouse liver. Taken together, these genes are all associated with inflammation/oxidative stress, consistent with the PPARA-dependent attenuation by Gm15441 of TXNIP-associated hepatic inflammation in response to metabolic stress.
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