Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_1
Snippet: although it is predicted to prevent release of viral contents into the cytosol by 86 preventing pore formation on the endosomal compartments where it is 87 suggested to reside. Here we have shown that the expression level of IFITM3 88 is important in determining the control of influenza virus infection. We find an 89 expression pattern for IFITM3 that varies based on cell type, tissue locality, 90 differentiation state and cell naivety, all of wh.....
Document: although it is predicted to prevent release of viral contents into the cytosol by 86 preventing pore formation on the endosomal compartments where it is 87 suggested to reside. Here we have shown that the expression level of IFITM3 88 is important in determining the control of influenza virus infection. We find an 89 expression pattern for IFITM3 that varies based on cell type, tissue locality, 90 differentiation state and cell naivety, all of which highlights cells that may be at 91 the highest risk of influenza infection. 92
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