Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_34
Snippet: As an ISG, it is possible that the pattern of IFITM3 expression seen above is 368 standard for all ISGs. To investigate this, we measured expression levels of 369 STAT1 and BST2 in the same samples as above. STAT1 and BST2, in the 370 same way as IFITM3, were previously reported to be expressed highly in stem 371 cells with expression lost following differentiation (4). STAT1 is a transcription 372 factor (20) and thus acted as an intracellular c.....
Document: As an ISG, it is possible that the pattern of IFITM3 expression seen above is 368 standard for all ISGs. To investigate this, we measured expression levels of 369 STAT1 and BST2 in the same samples as above. STAT1 and BST2, in the 370 same way as IFITM3, were previously reported to be expressed highly in stem 371 cells with expression lost following differentiation (4). STAT1 is a transcription 372 factor (20) and thus acted as an intracellular control against IFITM3. BST2, or 373 tetherin, tethers viruses (including IAV) to the cell surface to prevent viral 374 release and increase restriction of enveloped viruses (21). 375
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