Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_57
Snippet: To investigate the time required for IFITM3 induction following IFN 487 stimulation, we measured IFITM3 expression across 72 hours following IFN 488 stimulation (Figure 6) . In both HEK293 (Figure 6a ) and A549 (Figure 6b We found large variability in the basal expression of IFITM3 on different 507 cell types, with higher expression consistently on myeloid cells compared to 508 lymphoid. Minimal variability in this pattern is apparent with strong.....
Document: To investigate the time required for IFITM3 induction following IFN 487 stimulation, we measured IFITM3 expression across 72 hours following IFN 488 stimulation (Figure 6) . In both HEK293 (Figure 6a ) and A549 (Figure 6b We found large variability in the basal expression of IFITM3 on different 507 cell types, with higher expression consistently on myeloid cells compared to 508 lymphoid. Minimal variability in this pattern is apparent with strong clustering 509 between expression levels in multiple donors, suggesting that the pattern 510 seen here is robust and reproducible. This combined with the data from the 511 iPSC cells naturally and following differentiation into macrophages, strongly 512 suggests that the cell type and lineage alters basal IFITM3 levels. 513
Search related documents:
Co phrase search for related documents- basal expression and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- basal expression and high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- basal expression and ipsc cell: 1
- basal expression and large variability: 1
- basal expression and myeloid cell: 1, 2
- cell type and expression level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32
- cell type and high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53
- cell type and ipsc cell: 1, 2, 3, 4
- cell type and lineage cell type: 1, 2, 3, 4, 5, 6
- cell type and myeloid cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- consistently high expression and expression level: 1
- consistently high expression and high expression: 1, 2, 3
- expression level and high expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78
- expression level and ipsc cell: 1, 2
- expression level and large variability: 1, 2
- expression level and macrophage differentiation: 1, 2
- expression level and myeloid cell: 1, 2, 3, 4
- high expression and large variability: 1
- high expression and myeloid cell: 1, 2, 3, 4, 5, 6, 7, 8, 9
Co phrase search for related documents, hyperlinks ordered by date