Author: Singh, Kamaljit; Kaur, Hardeep; Chibale, Kelly; Balzarini, Jan
Title: Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies Cord-id: h4zg0q8x Document date: 2013_6_10
ID: h4zg0q8x
Snippet: One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as
Document: One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of quinoline with pyrimidine have been synthesized and evaluated for their antiplasmodial activity against both CQ(S) and CQ(R) strains of Plasmodium falciparum. These depicted activity in nanomolar range and were found to bind to heme as well as AT rich pUC18 DNA.
Search related documents:
Co phrase search for related documents- acetate methanol and active compound: 1
- acetate methanol and activity profile: 1
- acid synthesis and action study: 1
- acid synthesis and active compound: 1
- acid synthesis and activity profile: 1
- acid synthesis and low concentration: 1, 2, 3
- active compound and low concentration: 1
Co phrase search for related documents, hyperlinks ordered by date