Selected article for: "cytokine release and pro inflammatory cytokine"
Author: Krett, Jonathan D.; Jewett, Gordon A.E.; Elton-Lacasse, Charissa; Fonseca, Kevin; Hahn, Christopher; Au, Selena; Koch, Marcus W.
Title: Hemorrhagic encephalopathy associated with COVID-19
  • Cord-id: ey30t0hr
  • Document date: 2020_7_14
    • ID: ey30t0hr
    Snippet: The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release sy
    Document: The mechanisms for neurological complications of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), are not yet well understood. We present a critically ill man with a COVID-19-associated hemorrhagic encephalopathy. SARS-CoV-2 RNA was not detected in cerebrospinal fluid (CSF) or blood. CSF analyses suggested dysregulation of pro-inflammatory cytokine pathways, particularly tumor necrosis factor-α and interleukin-6, consistent with a cytokine release syndrome. The patient gradually recovered with supportive care and neurological rehabilitation. Awareness of this clinical entity may facilitate the identification of patients with a potentially remediable cause of encephalopathy in COVID-19.

    Search related documents:
    Co phrase search for related documents
    • active discovery and acute respiratory syndrome: 1, 2, 3, 4, 5, 6
    • acute kidney injury and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute kidney injury and lumbar puncture: 1
    • acute pathology and admission day: 1, 2
    • acute pathology and lumbar puncture: 1
    • acute respiratory syndrome and admission day: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute respiratory syndrome and lumbar puncture: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • acute respiratory syndrome and lupus anticoagulant: 1, 2, 3, 4, 5, 6, 7
    • admission day and lumbar puncture: 1, 2, 3, 4, 5
    • admission day and lupus anticoagulant: 1, 2