Author: AJ Venkatakrishnan; Arjun Puranik; Akash Anand; David Zemmour; Xiang Yao; Xiaoying Wu; Ramakrishna Chilaka; Dariusz K Murakowski; Kristopher Standish; Bharathwaj Raghunathan; Tyler Wagner; Enrique Garcia-Rivera; Hugo Solomon; Abhinav Garg; Rakesh Barve; Anuli Anyanwu-Ofili; Najat Khan; Venky Soundararajan
Title: Knowledge synthesis from 100 million biomedical documents augments the deep expression profiling of coronavirus receptors Document date: 2020_3_29
ID: j7t9nebs_26
Snippet: We then asked whether this shared pattern of transcriptional heterogeneity among coronavirus receptors is observed in the human small intestine. Indeed, among all enterocytes from a human scRNA-seq study, both ANPEP and DPP4 were among the top 1% of genes with similar expression vectors to that of ACE2 ( Figure S22A-B) . We independently validated this observation by computing gene expression correlations from bulk RNA-sequencing of human small i.....
Document: We then asked whether this shared pattern of transcriptional heterogeneity among coronavirus receptors is observed in the human small intestine. Indeed, among all enterocytes from a human scRNA-seq study, both ANPEP and DPP4 were among the top 1% of genes with similar expression vectors to that of ACE2 ( Figure S22A-B) . We independently validated this observation by computing gene expression correlations from bulk RNA-sequencing of human small intestine samples from GTEx (n = 187), which similarly revealed that DPP4 and ANPEP are among the top 1% of correlated genes to ACE2 ( Figure S22C ). In fact, among all ~18,500 genes mean expression > 1 TPM in GTEx small intestine samples, DPP4 shows the second highest correlation to ACE2 (r = 0.95).
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