An appraisal of respiratory system compliance in mechanically ventilated covid-19 patients

Li Bassi, Gianluigi; Suen, Jacky Y.; Dalton, Heidi J.; White, Nicole; Shrapnel, Sally; Fanning, Jonathon P.; Liquet, Benoit; Hinton, Samuel; Vuorinen, Aapeli; Booth, Gareth; Millar, Jonathan E.; Forsyth, Simon; Panigada, Mauro; Laffey, John; Brodie, Daniel; Fan, Eddy; Torres, Antoni; Chiumello, Davide; Corley, Amanda; Elhazmi, Alyaa; Hodgson, Carol; Ichiba, Shingo; Luna, Carlos; Murthy, Srinivas; Nichol, Alistair; Ng, Pauline Yeung; Ogino, Mark; Pesenti, Antonio; Trieu, Huynh Trung; Fraser, John F.

BACKGROUND: Heterogeneous respiratory system static compliance (C(RS)) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported in previous small-case series or studies conducted at a national level. METHODS: We designed a retrospective observational cohort study with rapid data gathering from the international COVID-19 Critical Care Consortium study to comprehensively describe C(RS)—calculated as: tidal volume/[airway plateau pressure-positive end-expiratory pressure (PEEP)]—and its association with ventilatory management and outcomes of COVID-19 patients on mechanical ventilation (MV), admitted to intensive care units (ICU) worldwide. RESULTS: We studied 745 patients from 22 countries, who required admission to the ICU and MV from January 14 to December 31, 2020, and presented at least one value of C(RS) within the first seven days of MV. Median (IQR) age was 62 (52–71), patients were predominantly males (68%) and from Europe/North and South America (88%). C(RS), within 48 h from endotracheal intubation, was available in 649 patients and was neither associated with the duration from onset of symptoms to commencement of MV (p = 0.417) nor with PaO(2)/FiO(2) (p = 0.100). Females presented lower C(RS) than males (95% CI of C(RS) difference between females-males: − 11.8 to − 7.4 mL/cmH(2)O p < 0.001), and although females presented higher body mass index (BMI), association of BMI with C(RS) was marginal (p = 0.139). Ventilatory management varied across C(RS) range, resulting in a significant association between C(RS) and driving pressure (estimated decrease − 0.31 cmH(2)O/L per mL/cmH(2)0 of C(RS), 95% CI − 0.48 to − 0.14, p < 0.001). Overall, 28-day ICU mortality, accounting for the competing risk of being discharged within the period, was 35.6% (SE 1.7). Cox proportional hazard analysis demonstrated that C(RS) (+ 10 mL/cm H(2)O) was only associated with being discharge from the ICU within 28 days (HR 1.14, 95% CI 1.02–1.28, p = 0.018). CONCLUSIONS: This multicentre report provides a comprehensive account of C(RS) in COVID-19 patients on MV. C(RS) measured within 48 h from commencement of MV has marginal predictive value for 28-day mortality, but was associated with being discharged from ICU within the same period. Trial documentation: Available at https://www.covid-critical.com/study. Trial registration: ACTRN12620000421932.