Importance of suppression and mitigation measures in managing COVID-19 outbreaks

Hochberg, Michael E.

I employ a simple mathematical model of an epidemic process to evaluate how four basic quantities: the reproduction number (R), the numbers of sensitive (S) and infectious individuals(I), and total community size (N) affect strategies to control COVID-19. Numerical simulations show that strict suppression measures at the beginning of an epidemic can create low infectious numbers, which thereafter can be managed by mitigation measures over longer periods to flatten the epidemic curve. The stronger the suppression measure, the faster it achieves the low numbers of infections that are conducive to subsequent management. We discuss the predictions of this analysis and how it fits into longer-term sequences of measures, including using the herd immunity concept to leverage acquired immunity.