Life course exposures continually shape antibody profile and risk of seroconversion to influenza

Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org /10.1101/2020.01.15.19015693 doi: medRxiv preprint Fig. 2 . HAI titers and differences in HAI titers between two visits against historical H3N2 strains. Panel A and B: HAI titers against H3N2 strains from serum collected from baseline and follow-up visit, respectively. Participants are sorted by age at baseline sampling. Panel C: Fold of changes of HAI titers between two visits. Cell of row i and column j represents HAI titer or differences of HAI between two visits to strain i for person j. Panel D-F: Distribution of HAI titers from serum collected from baseline (D), follow-up visit (E), and fold of changes between two visits (F), respectively. Distributions were plotted after grouping titers across all participants and all tested H3N2 strains. (G) Variations of HAI titers at baseline with ages of participants and the year of isolation of tested strains. Dashed lines represent birth years of the participants (same for panel H and I). (H) Variations of HAI titers at follow-up with ages of participants and the year of isolation of tested strains. (I) Variation of changes in HAI titers between the two visits with ages of participants and the year of isolation of tested strains.