Selected article for: "challenge strain and immune response"
Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza
  • Document date: 2020_1_16
    • ID: cyxn7dpw_4
    Snippet: Historically, most studies have focused on measuring antibodies to a single strain or small set of strains of a subtype, either to measure the incidence of influenza through changes in titers (9) (10) (11) or as a proxy for immunity (e.g., as an endpoint in vaccine efficacy studies) (12) (13) (14) (15) . Exceptions do exist, and studies of multi-strain dynamics after immunological challenge date back to at least 1941 (16) . However, historically,.....
    Document: Historically, most studies have focused on measuring antibodies to a single strain or small set of strains of a subtype, either to measure the incidence of influenza through changes in titers (9) (10) (11) or as a proxy for immunity (e.g., as an endpoint in vaccine efficacy studies) (12) (13) (14) (15) . Exceptions do exist, and studies of multi-strain dynamics after immunological challenge date back to at least 1941 (16) . However, historically, few analytical approaches were available with which to interpret these complex data. In recent years there has been increasing interest in measuring and interpreting the breadth and strength of antigenic profiles across a diverse set of influenza strains (4, 7) . It is believed to provide a more nuanced picture of the humoral immune response to influenza than measuring titers to single strains (i.e. homologous titers), while the quantitative role of past exposures in determining risk of future infections and subsequent immune responses is still unclear.

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