Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_96
Snippet: We characterized the age distribution among titers that showed varying changes, i.e. decrease, no change, two-fold increase and four-fold increase ( fig. S8 ). We compared these distributions with the underlying age distribution of participants (table S1) who provided sera using Fishers' exact test. There appeared to be a higher proportion of people aged 10-20 years old (14.4%; 95%CI, 9.0% to 21.3%) and a lower proportion of people aged 40-50 yea.....
Document: We characterized the age distribution among titers that showed varying changes, i.e. decrease, no change, two-fold increase and four-fold increase ( fig. S8 ). We compared these distributions with the underlying age distribution of participants (table S1) who provided sera using Fishers' exact test. There appeared to be a higher proportion of people aged 10-20 years old (14.4%; 95%CI, 9.0% to 21.3%) and a lower proportion of people aged 40-50 years (23.0%; 95% CI, 16.3% to 30.9%) of participants who experienced decreased titers compared to all participants (Fisher's exact test, P = 0.03, fig. S8E ). There was no difference in the age distributions of participants who had unchanged, any-fold increased or seroconversion and the underlying age distribution of participants (Fisher's exact test, P > 0.05, fig. S8 F and H) .
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