Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress Document date: 2019_6_20
ID: dt0b7jnu_5
Snippet: Studies have also shown that NLRP3 inflammasome activity is attenuated by mono-and polyunsaturated fatty acids, which are endogenous PPARA agonists (Forman et al., 1997; Kliewer et al., 1997; Mochizuki et al., 2006; Ralston et al., 2017; Shen et al., 2017) . Considering these studies, a regulatory mechanism was proposed whereby fatty acids mobilized from adipose tissue during fasting activate PPARA, which in turn suppresses the NLRP3 inflammasome.....
Document: Studies have also shown that NLRP3 inflammasome activity is attenuated by mono-and polyunsaturated fatty acids, which are endogenous PPARA agonists (Forman et al., 1997; Kliewer et al., 1997; Mochizuki et al., 2006; Ralston et al., 2017; Shen et al., 2017) . Considering these studies, a regulatory mechanism was proposed whereby fatty acids mobilized from adipose tissue during fasting activate PPARA, which in turn suppresses the NLRP3 inflammasome by strong induction of the TXNIP-suppressing lncRNA gene Gm15441, which is antisense to Txnip. ChIPseq datasets were analyzed for PPARA binding sites within the Gm15441 promoter and Gm15441 regulatory elements were confirmed using reporter gene assays and PPARA ChIP studies.
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