Selected article for: "binding affinity and SARS high binding affinity"

Author: ENGIN, Ayse Basak; ENGIN, Evren Doruk; ENGIN, Atilla
Title: Current opinion in neurological manifestations of SARS-CoV-2 infection
  • Cord-id: puh97gfj
  • Document date: 2021_3_29
  • ID: puh97gfj
    Snippet: Neurological symptoms occur in approximately one third of hospitalized patients with coronavirus disease 2019 (COVID-19). Among these symptoms, hypoxic encephalopathy develops in one-fifth of severe cases, while ischemic strokes due to thrombotic complications are common in one-third of COVID-19 intensive care patients. Brain involvement of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is eventuated by several routes, including hematogenous spread, trans-synaptic entry through inf
    Document: Neurological symptoms occur in approximately one third of hospitalized patients with coronavirus disease 2019 (COVID-19). Among these symptoms, hypoxic encephalopathy develops in one-fifth of severe cases, while ischemic strokes due to thrombotic complications are common in one-third of COVID-19 intensive care patients. Brain involvement of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is eventuated by several routes, including hematogenous spread, trans-synaptic entry through infected neurons, olfactory nerve, ocular epithelium, vascular endothelium and impaired blood–brain barrier. Besides the high angiotensin converting enzyme-2 (ACE2) binding affinity, and FURIN preactivation, SARS-CoV-2 maintains efficient neuronal entry while evading immune surveillance by utilizing basigin, and neuropilin-1 receptors. However, the neurological manifestations and their pathogenic mechanisms are still debated in COVID-19 patients.

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