Author: Michael M. Lutz; Megan P. Worth; Meleana M. Hinchman; John S. L. Parker; Emily D. Ledgerwood
Title: Mammalian orthoreovirus infection is enhanced in cells pre-treated with sodium arsenite Document date: 2019_2_20
ID: cpfwzudq_41
Snippet: Infection with reovirus results in increased expression of stress response genes 486 including Hsc70, and GADD34, the latter of which complexes with protein phosphatase 1 487 to reverse eIF2α phosphorylation. We observed that Type 3 Dearing (T3D) reovirus 488 protein expression was unaffected in the presence of salubrinal, a selective inhibitor of 489 the GADD34/PP1α complex responsible for dephosphorylating eIF2α, even in cells pre-490 treate.....
Document: Infection with reovirus results in increased expression of stress response genes 486 including Hsc70, and GADD34, the latter of which complexes with protein phosphatase 1 487 to reverse eIF2α phosphorylation. We observed that Type 3 Dearing (T3D) reovirus 488 protein expression was unaffected in the presence of salubrinal, a selective inhibitor of 489 the GADD34/PP1α complex responsible for dephosphorylating eIF2α, even in cells pre-490 treated with SA to elevate the level of phosphorylated eIF2α. The observation that 491
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