Author: Francisca Verdugo-Paiva; Ariel Izcovich; Martin Ragusa; Gabriel Rada
Title: Lopinavir/ritonavir f?or the treatment of COVID-19: A living systematic review protocol Document date: 2020_4_17
ID: mhi6w4mr_3
Snippet: Lopinavir/ritonavir is a fixed-dose combination antiviral widely used for HIV infection and it has been suggested as a possible treatment in the context of the COVID-19 pandemic in 2019/2020. The information about its antiviral properties against coronavirus comes from its use in the previous SARS-CoV and MERS-CoV pandemics. In vitro studies demonstrated an antiviral activity of lopinavir/ritonavir against SARS-CoV [9] and clinical studies report.....
Document: Lopinavir/ritonavir is a fixed-dose combination antiviral widely used for HIV infection and it has been suggested as a possible treatment in the context of the COVID-19 pandemic in 2019/2020. The information about its antiviral properties against coronavirus comes from its use in the previous SARS-CoV and MERS-CoV pandemics. In vitro studies demonstrated an antiviral activity of lopinavir/ritonavir against SARS-CoV [9] and clinical studies reported a reduction in the intubation rate, steroid requirements and mortality with lopinavir/ritonavir in SARS patients [10] .
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