Author: Gregorova, Michaela; Morse, Daniel; Brignoli, Tarcisio; Steventon, Joseph; Hamilton, Fergus; Albur, Mahableshwar; Arnold, David; Thomas, Matthew; Halliday, Alice; Baum, Holly; Rice, Christopher; Avison, Matthew B; Davidson, Andrew D; Santopaolo, Marianna; Oliver, Elizabeth; Goenka, Anu; Finn, Adam; Wooldridge, Linda; Amulic, Borko; Boyton, Rosemary J; Altmann, Daniel M; Butler, David K; McMurray, Claire; Stockton, Joanna; Nicholls, Sam; Cooper, Charles; Loman, Nicholas; Cox, Michael J; Rivino, Laura; Massey, Ruth C
Title: Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia Cord-id: v22e74gs Document date: 2020_12_17
ID: v22e74gs
Snippet: Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persi
Document: Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.
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