Author: Michael M. Lutz; Megan P. Worth; Meleana M. Hinchman; John S. L. Parker; Emily D. Ledgerwood
Title: Mammalian orthoreovirus infection is enhanced in cells pre-treated with sodium arsenite Document date: 2019_2_20
ID: cpfwzudq_32
Snippet: In this report, we find that treatment of cells with sodium arsenite (SA), a potent 392 inducer of the integrated stress response (ISR) and eIF2α phosphorylation, prior to 393 inoculation with reovirus is beneficial to the virus in a strain-independent but cell-type-394 specific manner. SA treatment induces the formation of reactive oxygen species (ROS) 395 within cells. The increased intracellular ROS in turn lead to activation of HRI, which th.....
Document: In this report, we find that treatment of cells with sodium arsenite (SA), a potent 392 inducer of the integrated stress response (ISR) and eIF2α phosphorylation, prior to 393 inoculation with reovirus is beneficial to the virus in a strain-independent but cell-type-394 specific manner. SA treatment induces the formation of reactive oxygen species (ROS) 395 within cells. The increased intracellular ROS in turn lead to activation of HRI, which then 396 phosphorylates eIF2α at serine residues 48 and 51 leading to general translation 397 repression and downstream activation of the integrated stress response. In order to mature 398 and become activated, HRI has to be in a complex with CDC37, PPP5C, and HSP90. In 399 addition to being activated by heme-deficiency, HRI is also activated by heat shock and 400 osmotic shock, but not by ER stress or by amino acid or serum starvation [7] . In contrast, 401
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