Selected article for: "activity inhibit and acute respiratory syndrome coronavirus"
Author: Liu, Xiaocao; Raghuvanshi, Ruma; Ceylan, Fatma Duygu; Bolling, Bradley W.
Title: Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity
  • Cord-id: v5hjkli3
  • Document date: 2020_11_12
    • ID: v5hjkli3
    Snippet: [Image: see text] Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inhibiting the interaction between the envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 is a potential antiviral therapeutic approach, but little is known about how dietary compounds interact with ACE2. The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3′,4′-hydroxylation inhibit recombinant hu
    Document: [Image: see text] Angiotensin-converting enzyme 2 (ACE2) is a host receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Inhibiting the interaction between the envelope spike glycoproteins (S-proteins) of SARS-CoV-2 and ACE2 is a potential antiviral therapeutic approach, but little is known about how dietary compounds interact with ACE2. The objective of this study was to determine if flavonoids and other polyphenols with B-ring 3′,4′-hydroxylation inhibit recombinant human (rh)ACE2 activity. rhACE2 activity was assessed with the fluorogenic substrate Mca-APK(Dnp). Polyphenols reduced rhACE2 activity by 15–66% at 10 μM. Rutin, quercetin-3-O-glucoside, tamarixetin, and 3,4-dihydroxyphenylacetic acid inhibited rhACE2 activity by 42–48%. Quercetin was the most potent rhACE2 inhibitor among the polyphenols tested, with an IC(50) of 4.48 μM. Thus, quercetin, its metabolites, and polyphenols with 3′,4′-hydroxylation inhibited rhACE2 activity at physiologically relevant concentrations in vitro.

    Search related documents:
    Co phrase search for related documents
    • absence presence and active site: 1, 2, 3, 4, 5, 6, 7, 8
    • absence presence and activity assay: 1, 2, 3, 4, 5, 6, 7, 8
    • absence presence and lung alveolar: 1, 2, 3
    • absence presence and lung damage: 1, 2
    • ace active site and active site: 1, 2, 3
    • ace activity and active site: 1, 2, 3, 4
    • ace activity and activity assay: 1, 2, 3, 4
    • ace activity and lung alveolar: 1
    • ace inhibition and active site: 1
    • acid serum level and lung damage: 1
    • active site and low catalytic efficiency: 1
    • active site and lung damage: 1
    • administration dosage and lung damage: 1