Selected article for: "il1b protein and inflammasome activation"
Author: Chad N. Brocker; Donghwan Kim; Tisha Melia; Kritika Karri; Thomas J. Velenosi; Shogo Takahashi; Jessica A. Bonzo; David J. Waxman; Frank J. Gonzalez
Title: Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress
  • Document date: 2019_6_20
    • ID: dt0b7jnu_28
    Snippet: Pharmacological activation of PPARA deregulates NRLP3 inflammasome activity in a mouse model of diabetes (Deng et al., 2017) and prolonged hepatic NLRP3 inflammasome activation leads to hepatocyte death, inflammation, and fibrosis. Thus, the TXNIP-mediated NLRP3 inflammasome pathway was examined. Txnip mRNA was significantly decreased by PPARA activation in livers of wild-type, Gm15441 +/+ mice, while TXNIP protein was elevated in livers of Gm154.....
    Document: Pharmacological activation of PPARA deregulates NRLP3 inflammasome activity in a mouse model of diabetes (Deng et al., 2017) and prolonged hepatic NLRP3 inflammasome activation leads to hepatocyte death, inflammation, and fibrosis. Thus, the TXNIP-mediated NLRP3 inflammasome pathway was examined. Txnip mRNA was significantly decreased by PPARA activation in livers of wild-type, Gm15441 +/+ mice, while TXNIP protein was elevated in livers of Gm15441 LSL mice. Furthermore, TXNIP-mediated NLRP3 inflammasome activation resulted in cleavage of CASP1 to its mature, proteolytically active form. Mature CASP1 subsequently cleaves target proteins including the proinflammatory cytokine IL1B to its corresponding mature, active form. Mature, cleaved CASP1 and IL1B protein were elevated in Gm15441 LSL mice, indicating an increase in inflammasome activation. These findings indicate that lncRNA Gm15441 suppresses the TXNIP-mediated NLRP3 inflammasome pathway in response to metabolic stress.

    Search related documents:
    Co phrase search for related documents
    • active form and mature active form: 1, 2, 3
    • casp1 cleavage and inflammasome activation: 1
    • casp1 cleavage and metabolic stress: 1
    • diabetes mouse model and fibrosis inflammation: 1
    • fibrosis inflammation and inflammasome activation: 1, 2, 3, 4, 5, 6, 7
    • fibrosis inflammation and inflammasome pathway: 1
    • il1b protein and inflammasome activation: 1, 2
    • inflammasome activation and LSL mouse: 1
    • inflammasome activation and metabolic stress: 1, 2, 3, 4, 5, 6, 7
    • inflammasome activity and metabolic stress: 1
    • inflammasome pathway and LSL mouse: 1
    • inflammasome pathway and metabolic stress: 1, 2
    • LSL mouse and metabolic stress: 1, 2