Author: Cheng Wang; Shaobo Wang; Daixi Li; Xia Zhao; Songling Han; Tao Wang; Gaomei Zhao; Yin Chen; Fang Chen; Jianqi Zhao; Liting Wang; Wei Sun; Yi Huang; Yongping Su; Dongqing Wei; Jinghong Zhao; Junping Wang
Title: Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2 Document date: 2020_3_31
ID: bzq1xxqb_9
Snippet: In the present study, we demonstrated that HD5 displayed a strong ability to prevent 2019-nCoV S1 to bind to intestinal epithelial cells by blocking the ligand-binding domain (LBD) of ACE2. Our findings unmasked the innate defense function of intestinal HD5 against 2019-nCoV, which may benefit the on-going development of preventive and therapeutic drugs......
Document: In the present study, we demonstrated that HD5 displayed a strong ability to prevent 2019-nCoV S1 to bind to intestinal epithelial cells by blocking the ligand-binding domain (LBD) of ACE2. Our findings unmasked the innate defense function of intestinal HD5 against 2019-nCoV, which may benefit the on-going development of preventive and therapeutic drugs.
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