3DBionotes COVID-19 Edition

Macias, Jose Ramon; Sanchez-Garcia, Ruben; Conesa, Pablo; Ramirez-Aportela, Erney; Martinez Gonzalez, Marta; Wert-Carvajal, Carlos; Parra-Perez, Alberto M; Segura Mora, Joan; Horrell, Sam; Thorn, Andrea; Sorzano, Carlos O S; Carazo, Jose Maria

SUMMARY: The web platform 3DBionotes-WS integrates multiple Web Services and an interactive Web Viewer to provide a unified environment in which biological annotations can be analyzed in their structural context. Since the COVID-19 outbreak, new structural data from many viral proteins have been provided at a very fast pace. This effort includes many cryogenic Electron Microscopy (cryo-EM) studies, together with more traditional ones (X-rays, NMR), using several modeling approaches and complemented with structural predictions. At the same time, a plethora of new genomics and interactomics information (including fragment screening and structure-based virtual screening efforts) have been made available from different servers. In this context we have developed 3DBionotes-COVID-19 as an answer to: (1) The need to explore multi-omics data in a unified context with a special focus on structural information and (2) the drive to incorporate quality measurements, especially in the form of advanced validation metrics for cryogenic Electron Microscopy. AVAILABILITY: https://3dbionotes.cnb.csic.es/ws/covid19 SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.