Author: Andrew J. McNamara; Pranav Danthi
Title: Loss of IKK subunits limits NF-?B signaling in reovirus infected cells Document date: 2019_11_15
ID: e13xm0mh_1
Snippet: unbiased RNA-seq based approach to measure gene expression induced by 23 transfected viral genomic RNA (vgRNA) and reovirus infection, we discovered that 24 mammalian reovirus inhibits host cell innate immune signaling. We found that while 25 vgRNA and reovirus infection both induce a similar IRF dependent gene expression 26 program, gene expression driven by the NF-κB family of transcription factors is lower in 27 infected cells. Potent agonist.....
Document: unbiased RNA-seq based approach to measure gene expression induced by 23 transfected viral genomic RNA (vgRNA) and reovirus infection, we discovered that 24 mammalian reovirus inhibits host cell innate immune signaling. We found that while 25 vgRNA and reovirus infection both induce a similar IRF dependent gene expression 26 program, gene expression driven by the NF-κB family of transcription factors is lower in 27 infected cells. Potent agonists of NF-κB, such as Tumor Necrosis Factor alpha (TNFα) 28 and vgRNA, failed to induce NF-κB dependent gene expression in infected cells. We 29 demonstrate that NF-κB signaling is blocked due to loss of critical members of the 30 Inhibitor of KappaB Kinase (IKK) complex, NF-κB Essential MOdifier (NEMO) and IKKβ. 31
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