Author: Wolff, Georg; Limpens, Ronald W. A. L.; Zevenhoven-Dobbe, Jessika C.; Laugks, Ulrike; Zheng, Shawn; de Jong, Anja W. M.; Koning, Roman I.; Agard, David A.; Grünewald, Kay; Koster, Abraham J.; Snijder, Eric J.; Bárcena, Montserrat
Title: A molecular pore spans the double membrane of the coronavirus replication organelle Cord-id: viubj28a Document date: 2020_9_11
ID: viubj28a
Snippet: Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we used cellular cryo–electron microscopy to visualize a molecular pore complex that
Document: Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we used cellular cryo–electron microscopy to visualize a molecular pore complex that spans both membranes of the double-membrane vesicle and would allow export of RNA to the cytosol. A hexameric assembly of a large viral transmembrane protein was found to form the core of the crown-shaped complex. This coronavirus-specific structure likely plays a key role in coronavirus replication and thus constitutes a potential drug target.
Search related documents:
Co phrase search for related documents- achieve resolution and acute sars cov respiratory syndrome coronavirus: 1, 2
- acute sars cov respiratory syndrome coronavirus and luminal side: 1
Co phrase search for related documents, hyperlinks ordered by date