Selected article for: "asymptomatic period and real time"
Author: Rivett, Lucy; Sridhar, Sushmita; Sparkes, Dominic; Routledge, Matthew; Jones, Nick K; Forrest, Sally; Young, Jamie; Pereira-Dias, Joana; Hamilton, William L; Ferris, Mark; Torok, M Estee; Meredith, Luke; Curran, Martin D; Fuller, Stewart; Chaudhry, Afzal; Shaw, Ashley; Samworth, Richard J; Bradley, John R; Dougan, Gordon; Smith, Kenneth GC; Lehner, Paul J; Matheson, Nicholas J; Wright, Giles; Goodfellow, Ian G; Baker, Stephen; Weekes, Michael P
Title: Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission
  • Cord-id: xcomjvaa
  • Document date: 2020_5_11
    • ID: xcomjvaa
    Snippet: Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymp
    Document: Significant differences exist in the availability of healthcare worker (HCW) SARS-CoV-2 testing between countries, and existing programmes focus on screening symptomatic rather than asymptomatic staff. Over a 3 week period (April 2020), 1032 asymptomatic HCWs were screened for SARS-CoV-2 in a large UK teaching hospital. Symptomatic staff and symptomatic household contacts were additionally tested. Real-time RT-PCR was used to detect viral RNA from a throat+nose self-swab. 3% of HCWs in the asymptomatic screening group tested positive for SARS-CoV-2. 17/30 (57%) were truly asymptomatic/pauci-symptomatic. 12/30 (40%) had experienced symptoms compatible with coronavirus disease 2019 (COVID-19)>7 days prior to testing, most self-isolating, returning well. Clusters of HCW infection were discovered on two independent wards. Viral genome sequencing showed that the majority of HCWs had the dominant lineage B∙1. Our data demonstrates the utility of comprehensive screening of HCWs with minimal or no symptoms. This approach will be critical for protecting patients and hospital staff.

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