Author: Ferreira, André C.; Soares, Vinicius Cardoso; de Azevedo-Quintanilha, Isaclaudia G.; Dias, Suelen da Silva Gomes; Fintelman-Rodrigues, Natalia; Sacramento, Carolina Q.; Mattos, Mayara; de Freitas, Caroline S.; Temerozo, Jairo R.; Teixeira, LÃvia; Damaceno Hottz, Eugenio; Barreto, Ester A.; Pão, Camila R. R.; Palhinha, Lohanna; Miranda, Milene; Bou-Habib, Dumith Chequer; Bozza, Fernando A.; Bozza, PatrÃcia T.; Souza, Thiago Moreno L.
Title: SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes Cord-id: ezoyfsse Document date: 2021_3_1
ID: ezoyfsse
Snippet: Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human m
Document: Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been associated with leukopenia and uncontrolled inflammatory response in critically ill patients. A better comprehension of SARS-CoV-2-induced monocyte death is essential for the identification of therapies capable to control the hyper-inflammation and reduce viral replication in patients with 2019 coronavirus disease (COVID-19). Here, we show that SARS-CoV-2 engages inflammasome and triggers pyroptosis in human monocytes, experimentally infected, and from patients under intensive care. Pyroptosis associated with caspase-1 activation, IL-1ß production, gasdermin D cleavage, and enhanced pro-inflammatory cytokine levels in human primary monocytes. At least in part, our results originally describe mechanisms by which monocytes, a central cellular component recruited from peripheral blood to respiratory tract, succumb to control severe COVID-19.
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