Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_72
Snippet: Another important factor is the time it takes for IFITM3 to be induced 564 following IFN stimulation. We found that in cell lines it takes around 36 hours 565 to reach maximal IFITM3 expression, a relatively slow rate for an ISG which 566 are usually induced rapidly within 12 hours. This is in agreement with a paper 567 recently published showing that ISGs can be grouped into four groups, those 568 that are induced within 3 hours, 6 hours, 12 hou.....
Document: Another important factor is the time it takes for IFITM3 to be induced 564 following IFN stimulation. We found that in cell lines it takes around 36 hours 565 to reach maximal IFITM3 expression, a relatively slow rate for an ISG which 566 are usually induced rapidly within 12 hours. This is in agreement with a paper 567 recently published showing that ISGs can be grouped into four groups, those 568 that are induced within 3 hours, 6 hours, 12 hours or take 24 hours. IFITM3 569 was within the 24 hour group, at which point the experiment was stopped (25). 570
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