Selected article for: "bias risk and subgroup analysis perform"
Author: Francisca Verdugo-Paiva; Ariel Izcovich; Martin Ragusa; Gabriel Rada
Title: Lopinavir/ritonavir f?or the treatment of COVID-19: A living systematic review protocol
  • Document date: 2020_4_17
    • ID: mhi6w4mr_58
    Snippet: We will perform subgroup analysis according to the definition of severe COVID-19 infection (i.e respiratory failure vs respiratory distress syndrome vs ICU requirement). In case we identify significant differences between subgroups (test for interaction <0.05) we will report the results of individual subgroups separately. We will perform sensitivity analysis excluding high risk of bias studies, and if non-randomised studies are used, excluding st.....
    Document: We will perform subgroup analysis according to the definition of severe COVID-19 infection (i.e respiratory failure vs respiratory distress syndrome vs ICU requirement). In case we identify significant differences between subgroups (test for interaction <0.05) we will report the results of individual subgroups separately. We will perform sensitivity analysis excluding high risk of bias studies, and if non-randomised studies are used, excluding studies that did not report adjusted estimates. In cases where the primary analysis effect estimates and the sensitivity analysis effect estimates significantly differ we will either present the low risk of bias -adjusted sensitivity analysis estimates -or present the primary analysis estimates but downgrading the certainty of the evidence because of risk of bias.

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