Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_15
Snippet: The intent of nATY is to help us understand how immunity to strains circulating at different times contribute to the overall immune profile. At the extremes, if the antibody response was completely dominated by early infections, nATY would track with birth year, while if all strains circulating in one's life were equally important, nATY would track with the midpoint of the time at risk (i.e. unweighted average isolation year of post-birth strains.....
Document: The intent of nATY is to help us understand how immunity to strains circulating at different times contribute to the overall immune profile. At the extremes, if the antibody response was completely dominated by early infections, nATY would track with birth year, while if all strains circulating in one's life were equally important, nATY would track with the midpoint of the time at risk (i.e. unweighted average isolation year of post-birth strains). Our empirical observations are more in line with the latter hypothesis; baseline nATY moved away from birth year at a rate of 0.50 years for every additional year of life (0.45 years at follow-up) (Fig. 3 , J and K).
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