Selected article for: "activation altered homing and acute sars infection"
Author: Perez-Gomez, A; Vitalle, J; Gasca-Capote, MC; Gutierrez-Valencia, A; Trujillo-Rodriguez, M; Serna-Gallego, A; Muñoz-Muela, E; Jimenez-Leon, MR; Rafii-El-Idrissi Benhnia, M; Rivas-Jeremias, I; Sotomayor, C; Roca-Oporto, C; Espinosa, N; Infante-Dominguez, C; Crespo-Rivas, JC; Fernández-Villar, A; Pérez-González, A; Lopez-Cortes, LF; Poveda, E; Ruiz-Mateos, E
Title: Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
  • Cord-id: ck8tsvgl
  • Document date: 2021_3_19
    • ID: ck8tsvgl
    Snippet: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the
    Document: Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and non-hospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers as CD86 and CD4 were only restored in previously non-hospitalized patients while integrin β7 and indoleamine 2,3- dyoxigenase (IDO) no restoration was observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.

    Search related documents:
    Co phrase search for related documents
    • activation altered homing and acute respiratory infection: 1
    • activation altered homing and acute sars: 1
    • activation altered homing and acute sars infection: 1
    • activation marker and acute ards respiratory distress syndrome: 1, 2
    • activation marker and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • activation marker and acute phase: 1, 2, 3, 4
    • activation marker and acute respiratory infection: 1, 2, 3, 4, 5, 6, 7
    • activation marker and acute sars: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • activation marker and acute sars infection: 1, 2, 3, 4
    • activation marker and acute severe mild: 1
    • activation marker and acute severe mild sars: 1
    • activation marker and long covid: 1, 2
    • activation marker and low expression: 1, 2
    • activation marker and lymph node: 1