Author: Bingyi Yang; Justin Lessler; Huachen Zhu; Chaoqiang Jiang; Jonathan M. Read; James A Hay; Kin On Kwok; Ruiyin Shen; Yi Guan; Steven Riley; Derek A.T. Cummings
Title: Life course exposures continually shape antibody profile and risk of seroconversion to influenza Document date: 2020_1_16
ID: cyxn7dpw_21
Snippet: We expect individuals of different ages to show different antibody profiles due to differences in lifetime influenza exposures. However, we found that our summary metrics did not monotonically increase with age. There is a gradual increase in the overall (nAUC) and breadth of immunity (nW 40 ) throughout childhood consistent with the accumulation of exposures (Fig. 3 , J and K and fig. S1) (3) (4) (5) . The observed decrease in nAUC and nW 40 amo.....
Document: We expect individuals of different ages to show different antibody profiles due to differences in lifetime influenza exposures. However, we found that our summary metrics did not monotonically increase with age. There is a gradual increase in the overall (nAUC) and breadth of immunity (nW 40 ) throughout childhood consistent with the accumulation of exposures (Fig. 3 , J and K and fig. S1) (3) (4) (5) . The observed decrease in nAUC and nW 40 among people aged 40 to 50 and age-independent changes in these metrics (Fig. 3 D and H) could suggest low HAI antibody among this age group, which could be due to high non-specific immune responses [e.g. antibodies against HA stalk and neuraminidase (NA) and cellular immune responses; (18) (19) (20) (21) (22) ]. These non-specific immunities, which may accumulate over multiple exposures and are not measured in our assay, could preventing people from being infected and producing updated, strain specific HA responses (19, 20, 23) .
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