Selected article for: "cell cell and viral infectivity"
Author: Michael M. Lutz; Megan P. Worth; Meleana M. Hinchman; John S. L. Parker; Emily D. Ledgerwood
Title: Mammalian orthoreovirus infection is enhanced in cells pre-treated with sodium arsenite
  • Document date: 2019_2_20
    • ID: cpfwzudq_44
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/555367 doi: bioRxiv preprint T3D infection in HeLa cells is unaffected by SA pre-treatment, whereas SA pre-treatment 505 is beneficial in other cell types including L cells, Overall, this study finds that sodium arsenite-induced activation of the ISR prior 507 to reovirus inoculation results in enhanced viral protein expression, in.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/555367 doi: bioRxiv preprint T3D infection in HeLa cells is unaffected by SA pre-treatment, whereas SA pre-treatment 505 is beneficial in other cell types including L cells, Overall, this study finds that sodium arsenite-induced activation of the ISR prior 507 to reovirus inoculation results in enhanced viral protein expression, increased infectivity 508 and higher viral yield. Furthermore, HRI kinase activation of the ISR is insufficient for 509 replication enhancement as both heat shock and sodium arsenite activate the HRI kinase, 510 but only sodium arsenite treatment was associated with increased viral infectivity and 511 higher yield. Finally, sodium arsenite-induced enhancement was observed across reovirus 512 strains but was not observed in all cell types suggesting a role for cell-type-specific 513

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