Personalized treatment interventions: nonpharmacological and natural treatment strategies in Alzheimer's disease.

Sagud, Marina; Tudor, Lucija; Pivac, Nela

IntroductionAlzheimer's disease (AD) is a slow, irreversible, progressive, complex, and fatal neurodegenerative disorder. Available pharmacological treatment, known for almost two decades, does not cure the disease, but only alleviates the symptoms, with various efficacy and different side-effects. Therefore, there is an unmet need to find other person-centered or personalized approaches to treat AD.Areas coveredThis article describes the application of precision medicine-like approaches utilizing nonpharmacological treatment strategies and the use of natural products in personalized care for patients with AD.Expert opinionDue to the heterogeneity of disease symptoms, somatic conditions, and patient preferences, there is definitely no "one size fits all "intervention. Therefore, individualized treatment choice is based on dementia stage, medical and psychiatric comorbidity, leading symptoms, patient preferences, and remaining capacity of the patient. In the absence of disease-modifying agents, a patient-centered, multidisciplinary team approach appears to be the best option to alleviate the heavy symptomatic burden in this unfortunate population. Hence, appropriate interventions can be offered along the AD continuum, while a better understanding of personal characteristics might help in establishing optimal individualized treatment, as well as its duration and intensity, to deliver interventions in the most effective ways.