Selected article for: "detection rate and high detection rate"
Author: Wang, Wei-Kung; Chen, Shey-Ying; Liu, I-Jung; Chen, Yee-Chun; Chen, Hui-Ling; Yang, Chao-Fu; Chen, Pei-Jer; Yeh, Shiou-Hwei; Kao, Chuan-Liang; Huang, Li-Min; Hsueh, Po-Ren; Wang, Jann-Tay; Sheng, Wang-Hwei; Fang, Chi-Tai; Hung, Chien-Ching; Hsieh, Szu-Min; Su, Chan-Ping; Chiang, Wen-Chu; Yang, Jyh-Yuan; Lin, Jih-Hui; Hsieh, Szu-Chia; Hu, Hsien-Ping; Chiang, Yu-Ping; Wang, Jin-Town; Yang, Pan-Chyr; Chang, Shan-Chwen
Title: Detection of SARS-associated Coronavirus in Throat Wash and Saliva in Early Diagnosis
  • Cord-id: zojhdnlu
  • Document date: 2004_7_25
    • ID: zojhdnlu
    Snippet: The severe acute respiratory syndrome–associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 x 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting
    Document: The severe acute respiratory syndrome–associated coronavirus (SARS-CoV) is thought to be transmitted primarily through dispersal of droplets, but little is known about the load of SARS-CoV in oral droplets. We examined oral specimens, including throat wash and saliva, and found large amounts of SARS-CoV RNA in both throat wash (9.58 x 10(2) to 5.93 x 10(6) copies/mL) and saliva (7.08 x 10(3) to 6.38 x 10(8) copies/mL) from all specimens of 17 consecutive probable SARS case-patients, supporting the possibility of transmission through oral droplets. Immunofluorescence study showed replication of SARS-CoV in the cells derived from throat wash, demonstrating the possibility of developing a convenient antigen detection assay. This finding, with the high detection rate a median of 4 days after disease onset and before the development of lung lesions in four patients, suggests that throat wash and saliva should be included in sample collection guidelines for SARS diagnosis.

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