Author: Paley, Elena L.
Title: Chapter 9 Metabolites of shikimate and tryptophan pathways in coronavirus disease (COVID-19) Cord-id: ysjnki5k Document date: 2021_12_31
ID: ysjnki5k
Snippet: Both Alzheimer disease (AD) and COVID-19 are age-dependent diseases with a high prevalence of obesity and diabetes. Proteomic and metabolomic profiling of sera from COVID-19 patients is discussed in this chapter. Some shikimate pathway-tryptophan metabolites are altered in the blood sera of severe COVID-19 versus healthy controls. Metabolites of bile acids increased in the sera of COVID-19 patients. In the serum metabolomics of severe COVID-19 patients versus healthy, serotonin was lower, −1.7
Document: Both Alzheimer disease (AD) and COVID-19 are age-dependent diseases with a high prevalence of obesity and diabetes. Proteomic and metabolomic profiling of sera from COVID-19 patients is discussed in this chapter. Some shikimate pathway-tryptophan metabolites are altered in the blood sera of severe COVID-19 versus healthy controls. Metabolites of bile acids increased in the sera of COVID-19 patients. In the serum metabolomics of severe COVID-19 patients versus healthy, serotonin was lower, −1.72 fold, and tryptophan was lower, −0.567 fold. The complete autopsy examinations may indicate that manifestations in different organs of COVID-19 patients can be caused by chronic and acute toxicity. This suggestion is consistent with data on serum metabolic profiling of COVID-19 patients.
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