Selected article for: "acute distress and liver disease"
Author: Lenti, Marco Vincenzo; Borrelli de Andreis, Federica; Pellegrino, Ivan; Klersy, Catherine; Merli, Stefania; Miceli, Emanuela; Aronico, Nicola; Mengoli, Caterina; Di Stefano, Michele; Cococcia, Sara; Santacroce, Giovanni; Soriano, Simone; Melazzini, Federica; Delliponti, Mariangela; Baldanti, Fausto; Triarico, Antonio; Corazza, Gino Roberto; Pinzani, Massimo; Di Sabatino, Antonio
Title: Impact of COVID-19 on liver function: results from an internal medicine unit in Northern Italy
  • Cord-id: hmyibkez
  • Document date: 2020_7_10
    • ID: hmyibkez
    Snippet: Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminot
    Document: Little is known regarding coronavirus disease 2019 (COVID-19) clinical spectrum in non-Asian populations. We herein describe the impact of COVID-19 on liver function in 100 COVID-19 consecutive patients (median age 70 years, range 25–97; 79 males) who were admitted to our internal medicine unit in March 2020. We retrospectively assessed liver function tests, taking into account demographic characteristics and clinical outcome. A patient was considered as having liver injury when alanine aminotransferase (ALT) was > 50 mU/ml, gamma-glutamyl transpeptidase (GGT) > 50 mU/ml, or total bilirubin > 1.1 mg/dl. Spearman correlation coefficient for laboratory data and bivariable analysis for mortality and/or need for intensive care were assessed. A minority of patients (18.6%) were obese, and most patients were non- or moderate-drinkers (88.5%). Liver function tests were altered in 62.4% of patients, and improved during follow-up. None of the seven patients with known chronic liver disease had liver decompensation. Only one patient developed acute liver failure. In patients with altered liver function tests, PaO(2)/FiO(2) < 200 was associated with greater mortality and need for intensive care (HR 2.34, 95% CI 1.07–5.11, p = 0.033). To conclude, a high prevalence of altered liver function tests was noticed in Italian patients with COVID-19, and this was associated with worse outcomes when developing severe acute respiratory distress syndrome. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11739-020-02425-w) contains supplementary material, which is available to authorized users.

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