Selected article for: "expression level and IAV infection"
Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection
  • Document date: 2019_12_23
    • ID: ahs2wdus_5
    Snippet: expression level dependent manner (1) and was integral for the overall 105 clearance of infection in a murine setting (2). The fact that most, if not all, 106 individuals who come into contact with IAV become actively infected suggests 107 that basal expression of IFITM3 in hosts is not sufficient to control IAV in the 108 early stages of an infection. Bringing into question whether this anti-viral host 109 response is an innate factor or induced.....
    Document: expression level dependent manner (1) and was integral for the overall 105 clearance of infection in a murine setting (2). The fact that most, if not all, 106 individuals who come into contact with IAV become actively infected suggests 107 that basal expression of IFITM3 in hosts is not sufficient to control IAV in the 108 early stages of an infection. Bringing into question whether this anti-viral host 109 response is an innate factor or induced to help at later stages of an infection. Recently, it has been demonstrated that IFITM3 expression, along with 118 several other IFN-stimulated genes (ISG), is high in stem cells potentially as a 119 protection mechanism against viral infection, with expression then lost with 120 differentiation (4). Online databases of IFITM3 RNA expression show large 121 variability in expression in different organs. The protein atlas database 122 suggests that protein levels of IFITM3 are also variable across cell types, 123 however it is likely that these results came from studies using antibodies that 124

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