Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_51
Snippet: As seen in the cell lines, only moderate increases in IFITM3 expression 468 were observed in the CD14 + monocyte and CD1c + DC populations following 469 type II IFN stimulation (IFN-γ) (Figure 5e ). Type III IFN (IFN-λ3), was found 470 to induce IFITM3 expression considerably in pDC cells only as no other 471 immune cell is known to express the receptor for this IFN. It has previously 472 been reported that pDC can secrete IFN-λ and respond to.....
Document: As seen in the cell lines, only moderate increases in IFITM3 expression 468 were observed in the CD14 + monocyte and CD1c + DC populations following 469 type II IFN stimulation (IFN-γ) (Figure 5e ). Type III IFN (IFN-λ3), was found 470 to induce IFITM3 expression considerably in pDC cells only as no other 471 immune cell is known to express the receptor for this IFN. It has previously 472 been reported that pDC can secrete IFN-λ and respond to the cytokine in an 473 autocrine manner to increase anti-viral responses (22). Here we show that 474
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