Lung-Kidney Cross-Talk

Husain-Syed, Faeq; Walmrath, Hans-Dieter; Birk, Horst-Walter

Awareness of the multifaceted lung and kidney interactions in the critically ill has increased considerably. Cardiogenic and noncardiogenic pulmonary edema represent two entities of pulmonary edema and differ significantly in terms of alveolar fluid clearance. Acute lung injury describes the breakdown of normal lung architecture with development of a high-permeability noncardiogenic pulmonary edema resulting from an inflammation/oxidant-mediated injury to the alveolar-capillary barrier and downregulation of the epithelial active ion transport system. Acute kidney injury is the most common organ dysfunction in patients with acute respiratory distress syndrome. It may develop as a result of blood gas disturbances that compromise renal blood flow and renal compensatory mechanisms; pulmonary hypertension, which may aggravate renal impairment by causing renal congestion and tissue edema; and mechanical ventilation–induced alterations, including systemic release of mediators, all which promote end-organ cell injury. Acute kidney injury, on the other hand, may initiate and perpetuate lung injury resulting from fluid overload and the systemic release of mediators that promote increased pulmonary vascular permeability, lung inflammation, and apoptosis, and breakdown of the transepithelial electrolyte and water transport, ultimately leading to respiratory failure. It is hoped that an in-depth understanding of the factors influencing lung-kidney interactions will encourage physicians to explore and develop new strategies for the benefit of the patient.