Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_56
Snippet: Low basal expression of IFITM3 may make some immune cells more at risk of 481 viral infection than others. From the lung samples above we showed that 482 lung-resident macrophages and epithelial cells have low basal expression of 483 IFITM3 that may make them more susceptible to IAV infection in the early 484 stages of infection. Rapid induction of higher IFITM3 expression following 485 infection is likely to be required for complete viral contro.....
Document: Low basal expression of IFITM3 may make some immune cells more at risk of 481 viral infection than others. From the lung samples above we showed that 482 lung-resident macrophages and epithelial cells have low basal expression of 483 IFITM3 that may make them more susceptible to IAV infection in the early 484 stages of infection. Rapid induction of higher IFITM3 expression following 485 infection is likely to be required for complete viral control. 486
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