Author: Dannielle Wellington; Zixi Yin; Liwei Zhang; Jessica Forbester; Kerry Kite; Henry Laurenson-Schafer; Shokouh Makvandi-Nejad; Boquan Jin; Emma Bowes; Krishnageetha Manoharan; David Maldonado-Perez; Clare Verill; Ian Humphreys; Tao Dong
Title: Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection Document date: 2019_12_23
ID: ahs2wdus_67
Snippet: Alternatively, it may be that other mechanisms can induce IFITM3 expression 539 in T cells, such as T cell activation through CD3/CD28 (23). Low IFITM3 540 expression in T cells could potentially explain why CD4 T cells become 541 chronically infected by HIV-1 despite evidence that IFITM3 can restrict HIV-1 542 (9, 24). Additionally, our data may explain why depletion of IFITM3 in CD4 T 543 cells had no effect on HIV-1 infection rates in previous.....
Document: Alternatively, it may be that other mechanisms can induce IFITM3 expression 539 in T cells, such as T cell activation through CD3/CD28 (23). Low IFITM3 540 expression in T cells could potentially explain why CD4 T cells become 541 chronically infected by HIV-1 despite evidence that IFITM3 can restrict HIV-1 542 (9, 24). Additionally, our data may explain why depletion of IFITM3 in CD4 T 543 cells had no effect on HIV-1 infection rates in previous experiments (1). 544
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