Author: James T. VanLeuven; Benjamin J. Ridenhour; Craig R. Miller; Tanya A. Miura
Title: Lung epithelial cells have virus-specific and shared gene expression responses to infection by diverse respiratory viruses Document date: 2016_12_2
ID: iedh762s_25
Snippet: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/090936 doi: bioRxiv preprint Supplemental table 1 contains the list of genes whose expression was significantly up-regulated by all 173 three viruses compared to mock-inoculated cells. These genes may reflect a global response of epithelial cells 174 to viral infe.....
Document: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/090936 doi: bioRxiv preprint Supplemental table 1 contains the list of genes whose expression was significantly up-regulated by all 173 three viruses compared to mock-inoculated cells. These genes may reflect a global response of epithelial cells 174 to viral infection. Several of the genes with the highest fold change values are involved in antiviral defense at 175 the level of infected cells (eg., Mx1, Bst2, Oas2, Gbp10) or recruitment of immune cells (eg., Cxcl10, Cxcl11, regulated by all three viruses have diverse functions (Table S2) . Some examples of genes that were down-179 regulated by all three viruses included genes that encode transmembrane proteins (Tmem 119, 231, 19, 50a,
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