Author: Deepak Kumar; Nitin Sharma; Murali Aarthy; Sanjeev Singh; Rajanish Giri
Title: Mechanistic insights into Zika virus NS3 helicase inhibition by Epigallocatechin-3-gallate: Supplementary Files Document date: 2019_1_26
ID: k11iupe0_20
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/530600 doi: bioRxiv preprint values were calculated as 295nM against NTPase site ( Figure 5C ). Additionally, the inhibitory potential of EGCG was determined using substrate velocity curves which showed inhibitory constant (K i ) of 0.387 ± 0.034 µM ( Figure 5D ). This result shows that EGCG molecule is quite capable of inhibiting NTPase activi.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/530600 doi: bioRxiv preprint values were calculated as 295nM against NTPase site ( Figure 5C ). Additionally, the inhibitory potential of EGCG was determined using substrate velocity curves which showed inhibitory constant (K i ) of 0.387 ± 0.034 µM ( Figure 5D ). This result shows that EGCG molecule is quite capable of inhibiting NTPase activity of NS3 helicase in low micromolar range and could act as potential lead backbone molecule for further inhibitor development.
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