Selected article for: "caspase protein cleavage and cell death"
Author: Maestre, Ana M.; Garzón, Ana; Rodríguez, Dolores
Title: Equine Torovirus (BEV) Induces Caspase-Mediated Apoptosis in Infected Cells
  • Cord-id: f7usy52w
  • Document date: 2011_6_15
    • ID: f7usy52w
    Snippet: Toroviruses are gastroenteritis causing agents that infect different animal species and humans. To date, very little is known about how toroviruses cause disease. Here, we describe for the first time that the prototype member of this genus, the equine torovirus Berne virus (BEV), induces apoptosis in infected cells at late times postinfection. Observation of BEV infected cells by electron microscopy revealed that by 24 hours postinfection some cells exhibited morphological characteristics of apo
    Document: Toroviruses are gastroenteritis causing agents that infect different animal species and humans. To date, very little is known about how toroviruses cause disease. Here, we describe for the first time that the prototype member of this genus, the equine torovirus Berne virus (BEV), induces apoptosis in infected cells at late times postinfection. Observation of BEV infected cells by electron microscopy revealed that by 24 hours postinfection some cells exhibited morphological characteristics of apoptotic cells. Based on this finding, we analyzed several apoptotic markers, and observed protein synthesis inhibition, rRNA and DNA degradation, nuclear fragmentation, caspase-mediated cleavage of PARP and eIF4GI, and PKR and eIF2α phosphorylation, all these processes taking place after peak virus production. We also determined that both cell death receptor and mitochondrial pathways are involved in the apoptosis process induced by BEV. BEV-induced apoptosis at late times postinfection, once viral progeny are produced, could facilitate viral dissemination in vivo and contribute to viral pathogenesis.

    Search related documents:
    Co phrase search for related documents
    • activation bid and acute severe respiratory syndrome: 1
    • activation lead and acute severe: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • activation lead and acute severe respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • activation lead and adapter protein: 1, 2
    • active bev replication and acute severe: 1
    • active bev replication and acute severe respiratory syndrome: 1
    • active form and acute severe: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active form and acute severe respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • active form and adapter protein: 1
    • activity impair and acute severe: 1, 2, 3
    • activity impair and acute severe respiratory syndrome: 1, 2, 3
    • acute severe and adapter protein: 1
    • acute severe and adaptor molecule: 1
    • acute severe and load control: 1, 2, 3, 4, 5, 6, 7
    • acute severe and load control infection: 1
    • acute severe respiratory syndrome and adapter protein: 1
    • acute severe respiratory syndrome and adaptor molecule: 1
    • acute severe respiratory syndrome and load control: 1, 2, 3, 4, 5, 6, 7
    • acute severe respiratory syndrome and load control infection: 1