Author: Jacob Peter Matson; Amy M. House; Gavin D. Grant; Huaitong Wu; Joanna Perez; Jeanette Gowen Cook
Title: Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence Document date: 2019_2_22
ID: dsbucda9_18
Snippet: We calculated the licensing window as a fraction of the total G1 length by dividing the licensing window time by the Cdc6 peak time and found that this window is in fact the same proportion of G1 in both the first and second cell cycles (Fig. 6E) . These data suggest that G1 during cell cycle re-entry is a stretched rather than delayed G1 compared to actively proliferating cells in the second cycle, and cells in the first cycle have a longer amou.....
Document: We calculated the licensing window as a fraction of the total G1 length by dividing the licensing window time by the Cdc6 peak time and found that this window is in fact the same proportion of G1 in both the first and second cell cycles (Fig. 6E) . These data suggest that G1 during cell cycle re-entry is a stretched rather than delayed G1 compared to actively proliferating cells in the second cycle, and cells in the first cycle have a longer amount of available time with high Cdc6 than cells in the second cycle. Cells in the first G1 have more potential time to load MCM and yet, enter S phase with less loaded MCM than cells in the second cycle. Taken together, these data suggest that cells in the first G1 after G0 load MCM slowly.
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